Observations on the Pathophysiology and Mechanisms for Cyclic Neutropenia
نویسندگان
چکیده
We review the basic pathology of cyclical neutropenia in both humans and the grey collie, and examine the role that mathematical modeling of hematopoietic cell production has played in our understanding of the origins of this fascinating dynamical disease.
منابع مشابه
Adult-onset cyclic neutropenia is associated with increased large granular lymphocytes.
Human cyclic neutropenia occurs in adults as well as children. Clinical illness is similar in the childhood and adult diseases, but distinctly different modes of onset suggest heterogeneity in its pathophysiology. We studied seven patients with cyclic neutropenia, three with disease acquired in adulthood, and four with the childhood-onset disorder. All three patients with adult-onset cyclic neu...
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